{IN USA} Post-doctoral Fellow Positions Available - 生技

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Postdoctoral fellow positions are available
immediately for studying signal transduction pathways
involved in prostate carcinogenesis. We study the
molecular mechanism underlying prostate cancer (PCa)
progression and metastasis regulated by androgens via
non-genomic signaling pathways. Our lab research
currently focuses on investigating the pathophysiology
of the advanced hormone-refractory PCa because novel
modalities for treating a disease at that stage are
urgently needed.

The projects require molecular and cellular biology
techniques and the experiments will also be involved
in small animals. It is expected that the person is
willing and be able to be participating to animal
experiments. Thus, although it is not required, it is
preferable the person having some experience in animal
experiments. The positions are available currently
and the starting date is negotiable. The starting
salary is negotiable.

Some of our research interests are described briefly
here and the details can be found at
http://www.unmc.edu/dept/biochemistry/index.cfm?conref=12

1) To investigate the molecular mechanism by which
human PCa cells can grow in the androgen-reduced
environment. In this project, we investigate the
interaction of ErbB-2 and cellular prostatic acid
phosphatase (cPAcP) in regulating androgen action on
cell proliferation.
Our data further reveal that redox signaling plays a
critical role in mediating androgen action on cell
proliferation. The cross-talk between androgens and
redox signaling is currently under investigations.

2) To improve the treatment for advanced PCa
patients. We investigate novel strategies, including
new applications of drugs, pro-drug development and
nanomedicine approach. We previously discovered that
mifepristone, i.e., RU486, can suppress
hormone-refractory PCa growth in xenograft animals.
Anecdotal clinical results were observed and clinical
trials are going on now.
Currently, we are analyzing the efficacy of
combinational treatment for androgen-independent PCa
cells, utilizing chemotherapeutic reagents plus
inhibitors to tyrosine phosphorylation pathway. We
are also developing novel reagents for expressing
genes specifically in PCa cells for gene therapy.

3) To identify new markers/targets for developing
novel therapies. In advanced prostate carcinomas,
neuroendocrine (NE) cells rise. To investigate the
role of these cells in PCa progression, we establish
NE cell lines derived from PCa cells. These US
patent-awarded NE cells will be useful for analyzing
functional molecules and for identifying key
biomarkers in diagnosis and/or as novel targets for
treatments.

We have very collaborative team members and are very
productive in prostate cancer research. We are
sincerely looking for team players to join our
research efforts of conquering prostate cancer.
Interested candidates please, including up-dated CV,
contact
Ming-Fong Lin, Ph.D.
Professor and Vice-Chair, Department of Biochemistry
and Molecular Biology
Professor, Eppley Institute for Cancer Research
Contact address:
Department of Biochemistry and Molecular Biology
University of Nebraska Medical Center
985870 Nebraska Medical center
Omaha, NE 68198-5870
E-mail: [email protected]
Web:http://www.unmc.edu/dept/biochemistry/index.cfm?conref=12


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